Targeted Therapy: Any Place in the Management of Chronic Adenotonsilitis

The mucosal layer of oral cavity and upper respiratory tract has a major role in protecting the human body from infectious agents. Waldeyer’s ring including tonsils and adenoid located at the junction of both the digestive and respiratory tracts provides also an immunological protaction [1]. New immune-biological tests have helped in recognition of tonsillar cells responsible for the immunity reactions. Recurrent or chronicadenotonsillar infections mainly occur in children and also may affect healthy subjects. Local dysfunction of the rhino-oro-pharyngeal epithelium of the host is the main cause of this entity; also some cases may be triggered by the systemic immunological deficiencies. This leads to inappropriate immunity reaction towards the infectious microorganisms that are characterized by recurrent adenotonsilitis [2].